When a blue alien corpse, (later revealed to be that of a Kree), given the designation "GH", was recovered by scientists, it was transferred to the Guest House after World War II. The scientists housed there then managed to synthesize the serum from the alien's bodily fluids.
After the death of Agent Phil Coulson, Director Fury "moved heaven and earth" to bring Coulson back to life, sanctioning a series of unethical, painful procedures to do so. GH.325 was used to regenerate Coulson's heart tissue, among other injuries, and was kept secret from Coulson and the rest of S.H.I.E.L.D. The experiments were kept off the books by Director Fury.
Later, Skye was fatally shot by Ian Quinn, forcing Coulson to dig into what resurrected him in the hopes that it would work on Skye. After finding the location of the facility and the name of the mysterious serum, Agents Coulson, Garrett, Ward and Fitz raided the facility and acquired the drug. Before escaping the impending detonation of the facility, Coulson found the source from which the serums originated, and was horrified by what he saw.
Upon learning of GH.325's true source, Coulson rushed to the Bus to stop his team from giving the drug to Skye, but arrived too late. Simmons was then instructed to monitor Skye for any side effects from the serum.
Personally interested in how the GH.325 could benefit humanity, Simmons hoped to recreate the drug by repeatedly analyzing Skye's blood. However, she was unable to discover anything unusual in the blood samples, even when comparing them to Coulson's blood. Simmon's wanted to send the samples to S.H.I.E.L.D for more detailed analysis, but Coulson denied her as he wanted to keep the drug a secret until he could talk to Director Fury and get some answers. She and Fitz later decide to sneak the blood samples into the Hub while Simmons is there during the mission to capture the Clairvoyant.
Raina was able to replicate GH.325 and gave it to Garret who was dying as his cybernetics couldn't keep him alive anymore. However, as Garrett's memories weren't replaced like Coulsons were, Garrett quickly became insane and began rambling about how he's "seen the future" and how he's "going to create a new world".
Drug Recipients Edit
- Phil Coulson
- John Garrett
- Sebastian Derik
- Rebecca Stevens (currently Janice Robbins) Deceased
- Lewis Seaver Deceased
- Cameron Klein (currently Hank Thompson)
- Two other Guest House patients Deceased
- Promotes significant and rapid cell regeneration, enough to fully heal wounds and even revive dead tissue.
- Is undetectable in the recipient's system after usage, making it difficult for analysis on its composition, and for replication.
- Frequently causes the subject to deteriorate mentally, displaying hypergraphia (one known case is the subconscious drawing of alien diagrams also known as the Words of creation, among other side-effects listed by Coulson in "Nothing Personal", such as aphasia, catatonia, and/or complete psychosis. It may well be that only Skye's part alien physiology has protected her from these undesirable effects.
- It's theorized that negative side effects of the drug are caused by the alien's own genetic memories trying to override the recipients own memories.