Dr. Holden Radcliffe is a scientist and transhumanist that was forced to help Hive with his plans for world domination.
His research is currently being monitored by S.H.I.E.L.D.
Early History Edit
Dr. Radcliffe is originally from Scotland and is a transhumanist, a person who believes in transcending normal human limitations with science and technology.
He was the lead researcher on parasitic organisms at GT Agrochemical. His goal was to genetically engineer animals that could resist parasites. However, he was asked to step-down for conducting "irregular" experiments. He left the lab a month before Giyera led an assault on the facility and killed all the scientist there.
The Singularity Edit
Fitz and Simmons believed Radcliffe could help them find a way to rescue Daisy as Hive uses parasites to brainwash his victims. They tracked him to Bucharest at black market spot for transhumanist. Fitz and Simmons planned to go undercover as geneticist and get Radcliffe's attention by offering him a pair of cybernetic eyes similar to the ones Deathlok has.
Fitz and Simmons talk to Radcliffe's assistant who tells them Dr. Radcliffe needs assurance that their cybernetic eyes work. She then leads them to an operating room where a man is lying in a chair and she tells them to implant the eyes inside this man and then hands them a tray of surgical equipment. However, Simmons realizes this man is actually Radcliffe himself when she notices his eyes are already prosthetic.
After examining the cybernetic eyes himself, Radcliffe becomes suspicious as to how they got this technology and assumes they're with Hydra, but Fitz and Simmons then confess they're with S.H.I.E.L.D. and came to ask him for help in rescuing Daisy. Radcliffe doesn't care, however, and orders his bodyguards to throw them out, but then Daisy and Hive burst through the door and abduct Radcliffe.
At the end of the episode, Radcliffe is seen walking with Hive as he explains how he wants Radcliffe to repeat the same experiment that the Kree performed on him which turned him into an inhuman on humans.
Failed Experiments Edit
Radcliffe performs his first experiment by injecting three Hydra agents with a serum containing terrigen and Hive's blood. However, the serum failed to turn them into inhumans and instead killed all three agents and caused their bodies to liquefy. Hive was angry at Radcliffe and Radcliffe explains he needs blood from a living Kree for the experiment to work.
Hives lures two Kree Reapers to Earths in the hope of using their blood for the experiment, but, with interference from S.H.I.E.L.D., both reapers die before their blood can be completely drained. Daisy, however, later reveals that she has Kree blood because she was injected with GH.325.
Using Daisy's blood, Radcliffe creates a pathogen designed to transform any human exposed to it into an inhuman. For Radcliffes first test of the pathogen, Hive abducts a team of Watchdogs and imprisons them inside a shipping container then Radcliffe fills the container with the pathogen gas.
When they open the container, they find all the Watchdogs have undergone terrigenesis and have been transformed into Primitive Inhumans. Radcliffe is horrified by what he has done and calls the Primitives abominations, but Hive is pleased with these results and orders Radcliffe to make more of the pathogen.
Hive devises a plan to use a warhead Hydra stole from the A.T.C.U. to spread the pathogen and transform millions of humans into Primitives. Hive takes Radcliffe with him to a military missile silo where Hive's followers quickly take control of the facility and force the technicians to launch a missile carrying the pathogen. However, moments before the missile was going to launch, S.H.I.E.L.D. aborts the launch and Hive orders Radcliffe to fix the launch system or he will kill him.
Radcliffe struggles to follow Hive's orders and comments how he isn't an engineer. May then barges into the room with a gun in hand and begins fighting the Primitives. During the fight, Radcliffe shoots a Primitive with May's gun and begs her to take her with him.
May takes Radcliffe back to the base where he meets Gen. Talbot. Talbot threatens to turn Radcliffe into a Primitive himself unless he finds some way to turn the people he already turned back into humans. Coulson has Fitz and Simmons work with Radcliffe on a solution.
Giyera and James detonate a pathogen bomb inside the base which turns several dozen S.H.I.E.L.D. agents into Primitives that then release Hive from his prison. The Primitives begin searching the base and killing anyone they find. Radcliffe follows Lincoln and Coulson and, together with Mack and Elena, they hide inside Mack's workshop. After Coulson comments how it's getting hotter, Radcliffe realizes that the Primitives can only see in infrared and Simmons must've realized this too which is why she has begun to raise the temperature as to make them invisible to the Primitives.
At the end of season three, Radcliffe enters his office and announces to his A.I., AIDA, that he's been officially cleared of all crimes he was charged with.
Furthermore, Radcliffe informs AIDA that he's starting a new project, based on an old S.H.I.E.L.D. program called Life Model Decoy (L.M.D.), and they're celebrating because today is AIDA's first birthday.
Season Four Edit
The Ghost Edit
Fitz visits Radcliffe at his home to watch a soccer game together, but is surprised when he sees AIDA walking around the house without clothes on. Radcliffe quickly covers AIDA, deactivates her, and explains that he was in the middle of installing some new hardware when he arrived.
With Fitz extremely confused, Radcliffe explains to him how AIDA was his digital assistant A.I., but Radcliffe designed AIDA's physical body based on the prosthetic hand they built for Coulson. Fitz then reminds Radcliffe that a condition of the pardon he was given for his crimes is that he isn't allowed to conduct unauthorized experiments like this. However, Fitz agrees to help Radcliffe finish AIDA after learning AIDA's designed to protect the lives of S.H.I.E.L.D. agents and to never kill humans.
Simmons brings May, who is currently suffering the effects of the "ghost virus", to Radcliffe's home hoping to use his latest invention, the Framework, to discover a way to cure May before the virus kills her. Using the Framework, they create a 3D hologram model of May's brain and find the source of May's hallucinations.
Radcliffe's solution is they temporarily stop May's heart, wait for her brain to reach minimum activity, and then restart her heart; similar to restarting a computer when it's glitching. Seeing no other options, Simmons goes through with Radcliffe's plan, but moments before she's about to restart May's heart an EMP created by the Inhuman Resistance causes a blackout.
While Simmons applies CPR, Radcliffe takes AIDA's battery, which has magnetic shielding and thus was protected from the EMP, and uses it to power a defibrillator which Simmons uses to revive May, who is now cured of the virus.
Deals with Our Devils Edit
After Elias's experiment causes Fitz, Robbie, and Coulson to disappear and gives Elias powers, Mace has Radcliffe examine the power cells Elias used to power his machine in order to gain insight into Elias's new abilities.
However, the technology inside the power cells was too advanced for Radcliffe to understand. After Mace leaves, May shows Radcliffe the Darkhold and explains how it may help him understand. However, after taking only a brief look inside the book Radcliffe immediately closes it, overwhelmed by what he saw.
AIDA then volunteers to read the Darkhold as she's an android, if her files becomes corrupted then they only need to reboot her. Radcliffe is at first against AIDA's idea, but May convinces him otherwise and using knowledge from the Darkhold AIDA builds an interdimensional gateway that Coulson, Fitz, and Robbie use to return to this reality.
- Radcliffe's eyes aren't entirely human, Simmons described them as some kind of bird-human genetic hybrid. When asked why, Radcliffe answered he was jealous of how birds have better eyesight than humans.